Zataria multiflora Alleviates Cisplatin-Induced Oxidative Stress, Apoptosis, and Nephrotoxicity in Mice

background: cisplatin (cp), as an anticancer drug, causes nephrotoxicity. zataria multiflora boiss (zm), a medicinal plant, has antioxidant and anti-inflammatory properties. objectives: the current study investigated the effects of zm on cisplatin-induced nephrotoxicity. methods: in the current experimental study, 22 male mice were randomly divided into four groups: the control; the zm, 200 mg/kg during seven days via gavage; the cp, 10 mg/kg intraperitoneally on the 5th day of study; and the zm + cp. serum creatinine and urea levels, malondialdehyde (mda), glutathione (gsh) and protein carbonyl (pc) levels in renal tissue of mice were histopathologically and immunohistochemically assessed to determine nephrotoxicity. results: cp caused a significant increase in serum creatinine and urea levels, increased oxidative stress in kidney tissue, caused histological changes, and increased caspase-3 immunoreactivity. zm significantly mitigated the toxic effects of cp on the kidney tissue. in addition, treatment with zm significantly reduced immunoreactivity of caspase-3. conclusions: the findings of the present study suggested that the zm as a potential antioxidant compound with scavenging free radicals and anti-apoptosis property attenuated the nephrotoxicity induced by cisplatin.