Title of article :
Allergic bronchopulmonary aspergillosis and severe asthma with fungal sensitization in patients with uncontrolled asthma: An experience from Southwestern Iran
Author/Authors :
Farjadian Shirin Department of Immunology - Shiraz University of Medical Sciences - Shiraz, Iran , Moghtaderi Mozhgan Allergy Research Center - Allergy Clinic of Ali-Asghar Hospital - Shiraz University of Medical Sciences - Shiraz, Iran , Teshnizi Hossieni Clinical Research Development Center of Children Hospital - Hormozgan University of Medical Sciences - Bandar Abbas, Iran , Hadibarhaghtalab Maryam Noncommunicable Disease Research Center - Fasa University of Medical Sciences - Fasa, Iran
Abstract :
Small fungal spores of the mold Aspergillus fumigatus
(AF), which is abundant worldwide, can easily reach the
lower airways and alveoli through inhalation (1, 2). In patients
with asthma, the prevalence of Aspergillus sensitization
is reported to be about 2% and it is more often associated
with severe type of asthma (3). The major types of respiratory
disease caused by these fungi are Aspergillus-induced
asthma (AIA), severe asthma with fungal sensitization
(SAFS), and allergic bronchopulmonary aspergillosis
(ABPA) in patients with asthma (4, 5).
Patients with asthma who have an immediate positive reaction
to the Aspergillus allergen without evidence of inflammation
or tissue damage are considered to have AIA
(2). The term SAFS was introduced in 2006 for patients
with asthma who had an immediate positive skin reaction
to Aspergillus antigens or elevated serum IgE levels to AF
accompanied by frequent exacerbations of respiratory
symptoms (4, 5)....
Keywords :
Allergic bronchopulmonary aspergillosis , severe asthma , fungal sensitization , patients , uncontrolled asthma , An experience from Southwestern Iran
Journal title :
Medical Journal of the Islamic Republic of Iran
