The Association between Burning Mouth Syndrome and Level of Thyroid Hormones in Hashimotos Thyroiditis in Public Hospitals in Shiraz, 2016

Statement of the Problem: Burning sensation in Hashimoto patient’s oral cavity is an unknown prevalent problem. Purpose: This study aimed to evaluate the prevalence and intensity of burning mouth syndrome (BMS) in patients suffering from Hashimoto’s thyroiditis in all public hospitals in Shiraz, 2016. Materials and Method: A total of 153 patients with Hashimoto’s thyroiditis were selected based on simple random sampling. The initial level of thyroid stimulating hormone (TSH), Anti-TPO (thyroperoxidase), Anti-TG (thyroglobu-lin), Free T3 (triiodothyronine) and Free T4 (thyroxine) serum as the indices of Hashimoto’s thyroiditis was assessed. The BMS intensity was measured accord-ing to each patient's verbal or nonverbal expression about the pain experience based on visual analog scale (VAS). Results: Based on the clinical evaluation and interview, only 19out of 153 cases (12%) reported BMS. The mean BMS was 3 based on VAS. Statistically signifi-cant association was detected between the level of TSH (p= 0.0001), Anti-TPO (p= 0.035), Anti-TG (p= 0.0001), Free T3 (p= 0.0001), Free T4 (p= 0.0001) indi-ces in patients with BMS. Significant association was also observed between the level of Anti-TPO (p= 0.0001), Anti-TG (p= 0.0001), Free T3 (p= 0.0001) and TSH (p= 0.0001) indices and BMS intensity. However, no significant association was found between the BMS severity and Free T4 (p= 0.056). Conclusion: The level of TSH, Anti-TPO, and Anti-TG, Free T3, and TSH indi-ces of Hashimoto’s patients were associated with the presence and severity of BSM. However, Free T4 level was only associated with the presence of BMS and not the intensity.