Title of article :
Synthesis of pyran derivatives via three component reaction of isocyanides
Author/Authors :
Ghasemi, Narges National Petrochemical Company (NPC) - petrochemical Research and Technology Company, Arak , Akbari, Reza Department of Chemistry - Gonbad Kavous University, Gonbad
Abstract :
The reaction between alkyl(aryl) isocyanides and dibenzoylacetylene in the presence of ethyl bromopyruvate leads
to ethyl 3,4-dibenzoyl-2-bromomethyl-5-alkyl(aryl)imino-2,5-dihydro-pyran-2-carboxylates in high yields in Nformylmorpholine as solvent. Dialkyl acetylenedicarboxylates react with tert-butyl isocyanide and ethyl bromopyruvate to
produce 3,4-dialkyl 2-ethyl 2-bromomethyl-5-tert-butylimino-2,5-dihydro-pyran-2,3,4-tricarboxylates.
Keywords :
Isocyanide , Ethyl bromopyrovate , Dibenzoylacetylene , Three-component reaction , Acetylenic ester
Journal title :
Iranian Journal of Organic Chemistry
