Author/Authors :
Sharif-Kashani, Babak Tobacco Prevention and Control Research Center - National Research Institute of Tuberculosis and Lung Disease - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Ghanbari Motlagh, Ali Department of Radiation Oncology - Imam Hossein Hospital - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Mafi, Ahmad R Department of Radiation Oncology - Imam Hossein Hospital - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Esnaashari, Omid Urmia Omid Hospital - Radiation and Oncology Center, Urmia, Iran , Ramzi, Mani Department of Medical Oncology and Hematology and Bone Marrow Transplantation - Hematology Research Center - Shiraz University of Medical Sciences, Iran , Taghizadeh, Ali Department of Radiation Oncology - Imam Reza University Hospital, Mashhad, Iran , Najafi, Safa Breast Diseases Department - Breast Cancer Research Center - Motamed Cancer Institute, ACECR, Tehran, Iran
Abstract :
Background: Venous thromboembolism (VTE) is one of the main causes of
mortality in patients with cancer. This study was conducted to assess the
incidence of deep vein thrombosis (DVT) in breast cancer patients receiving
outpatient cancer therapy.
Materials and Methods: This multi-center prospective cohort study was
conducted on patients with breast cancer, initiating an outpatient
chemotherapy regimen in five medical centers in Iran. Eligible patients were
enrolled in the study consecutively between January 2013 and January 2015.
The primary outcome was lower extremity DVT based on duplex/doppler
ultrasonography two months after the first course of chemotherapy (visit 2) and
after the end of the course (visit 3). All patients were followed-up from the
onset of chemotherapy until the first occurrence of lower extremity DVT, death,
or the end of the course.
Results: A total of 427 eligible breast cancer patients were recruited in the
study, 403 of whom attended at least one follow-up visit. The mean (SD)
duration of follow-up was 4 (1.3) months. During the follow-up, only one
patient showed DVT on duplex/doppler ultrasonography in visit 2. Therefore,
the two-month and overall cumulative incidence risk of DVT was 0.25% (95%
CI: 0.00–0.74%). However, the mean D-dimer level showed no significant
change (P>0.05).
Conclusion: Our findings showed the low risk of DVT in breast cancer patients
receiving outpatient cancer therapy.
Keywords :
Deep vein thrombosis , Breast cancer , Outpatient , Chemotherapy
