Title of article :
Estimation of Organ-Absorbed Doses in Human from Gamma Rays of 99mTc-DTPA Radiopharmaceutical, Using the Animal Dissection Data
Author/Authors :
Mohammadi, Bentol Hoda Department of Physics - Payame Noor University, Tehran , Shirmardi, Pezhman Radiation Application Research School - Nuclear Science and Technology Research Institute, Tehran , Shokri, Ali Asghar Department of Physics - Payame Noor University, Tehran , Erfani, Mostafa Radiation Application Research School - Nuclear Science and Technology Research Institute, Tehran
Abstract :
Introduction: Scintigraphy of renal system with radiopharmaceuticals extracts
provides us with essential information as to assist the diagnosis and
management of patients. In this research, effective doses of human’s organs
due to gamma-rays of 99mTc-DTPA are estimated using the animal dissection
data.
Materials and Methods: In this study, the human absorbed and effective doses
from 99mTc-DTPA are obtained from animal organs data, using medical internal
radiation dosimetry (MIRD) method and MCNP simulation code. In each stage,
three mice were injected and sacrificed, and then their organs were dissected
and counted by well detector.
Results: The results of MIRD and MCNP simulation code indicated that the
two mentioned methods are in agreement. Also, kidney (1.23E-03mGy/MBq),
spleen (2.81E-03 mGy/MBq) and heart (2.75E-03 mGy/MBq) absorbed the
most gamma dose compared to the other organs.
Conclusion: According to the results and comparison with ICRP data, animal
dissection model can be a useful tool for internal absorbed dose estimation of
renal radiopharmaceuticals.
Keywords :
MCNP simulation code , MIRD method , 99mTc- DTPA , Effective dose
Journal title :
Archives of Advances in Biosciences
