Preparation and characterization of fluorapatite-bioactive glass S53P4 nanocomposite

This research has been done to study characteristic and biocompatible evaluation of a nano-biocomposite ceramic with the bioglass (BG) as a first phase. In this regard, synthesis of S53P4 (53% SiO2, 4% P2O5, 23% Na2O and 20% CaO) bioglass has been considered as the first phase and flourapatite (FA) considered as the second phase. Afterwards, nanocomposite with the base of S53P4 bioglass has been synthesized by sol-gel method. The synthesized nanoparticles and nanocomposite have been characterized with the help of different techniques, using field emission scanning electron microscope (FESEM), X-ray diffraction (XRD), Fourier transforms infrared spectroscopy (FT-IR), X-ray fluorescence (XRF) to evaluate crystal structure, microstructure, and morphology. The results showed that the crystallite size and the crystallinity of S53P4 bioglass-fluorapatite nanocomposites were about 20-30 nm and 70-90%, respectively. The FT-IR analyses displayed that the purity in the structure of this nanocomposite. The result of MTT (3-(4,5-Dimethylthiazol-2-Yl)-2,5-Diphenyltetrazolium Bromide) assay indicated the nontoxicity and also decreasing of cell viability in 7 days compared with the first day.