Author/Authors :
Jiang, Kehua Department of Urology - Institute of Urology - Tongji Hospital - Tongji Medical College - Huazhong University of Science and Technology - Wuhan, China - Department of Urology - Guizhou provincial people's hospital - Guiyang, China , Tang, Kun Department of Urology - Institute of Urology - Tongji Hospital - Tongji Medical College - Huazhong University of Science and Technology - Wuhan, China , Liu, Haoran Department of Urology - Institute of Urology - Tongji Hospital - Tongji Medical College - Huazhong University of Science and Technology - Wuhan, China , Xu, Hua Department of Urology - Institute of Urology - Tongji Hospital - Tongji Medical College - Huazhong University of Science and Technology - Wuhan, China , Ye, Zhangqun Department of Urology - Institute of Urology - Tongji Hospital - Tongji Medical College - Huazhong University of Science and Technology - Wuhan, China , Chen, Zhiqiang Department of Urology - Institute of Urology - Tongji Hospital - Tongji Medical College - Huazhong University of Science and Technology - Wuhan, China
Abstract :
Purpose: The relationship of ascorbic acid (AA) supplements and risk of kidney stones among men and women is
controversial. This systematic evaluation was performed to obtain comprehensive evidence about the relationship
of AA supplements and risk of kidney stones among men and women.
Material and Methods: A systematic search of Pubmed, the Cochrane Library, Web of Science, Embase was
performed to identify studies that exhibited the relationship of AA supplements and risk of kidney stones among
men and women and were published up to Mar 2017. Outcomes of interest included kidney stones incidence and
risk factors.
Results: Four studies estimating the association between AA supplements and risk of kidney stones were included
for meta-analysis. The kidney stones incidence was significantly higher in men than women with AA supplements
(OR= 1.62; 95% CI: 1.09 to 2.42; P = 0.02). AA supplements (250-499mg/d, 1000-1499mg/d) was remarkably
correlated with the risk of renal stones among men (OR= 1.14, 95% CI: 1.00 to 1.28, P = 0.04; OR= 1.12, 95%
CI: 1.11 to 1.13, P < 0.00001; respectively). However, AA supplements (500-999 mg/d, >1500 mg/d) did not
correlate with the risk of renal stones among men (OR= 1.20, 95% CI: 0.99 to 1.46, P = 0.06; OR= 1.28, 95% CI:
1.00 to 1.63, P = 0.05; respectively). In addition, AA supplements (250-499mg/d, 500-999mg/d, 1000-1499mg/d,
>1500mg/d) did not remarkably correlate with the risk of renal stones among women (OR= 1.00, 95% CI: 0.82 to
1.22, P = 0.98; OR= 1.08, 95% CI: 0.99 to 1.18, P = 0.09; OR= 0.99, 95% CI: 0.90 to 1.08, P = 0.77; OR= 0.99,
95% CI: 0.99 to 1.09, P = 0.88; respectively).
Conclusion: AA supplements was remarkably correlated with higher risk for kidney stones incidence in men, but
not in women. Further multicenter, prospective and long-term follow-up RCTs are required to verify these findings.
Keywords :
Ascorbic acid , Vitamin C , Kidney stones , Oxalate , meta-analysis
