Title of article :
The effects of captopril on learning and memory impairment induced by scopolamine in rats: antioxidative effects
Author/Authors :
Akbari, Hamid Reza Mashhad University of Medical Sciences, Mashhad , Beheshti, Farimah Department of Physiology - School of Paramedical Sciences - Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh , Sadeghnia, Hamid Reza Mashhad University of Medical Sciences, Mashhad , Bafadam, Soleyman Mashhad University of Medical Sciences, Mashhad , Baghcheghi, Yousef Department of Physiology - Faculty of Medicine - Mashhad University of Medical Sciences, Mashhad , Hosseini, Mahmoud Mashhad University of Medical Sciences, Mashhad
Abstract :
Introduction: Angiotensin converting enzyme (ACE) inhibitors are suggested to have
some beneficial effects on the brain. In the present study the protective effects
against brain tissues oxidative damage as possible mechanism for learning and
memory improving effects of captopril was investigated in scopolamine treated rats.
Methods: Fifty male Wistar rats were divided into seven groups and treated: saline
as a control group, Sco (scopolamine) and Sco-Capto10, 50 and 100 (captopril 10, 50
and 100mg/kg before scopolamine). Treatment was passive avoidance test and then
the cortical tissues were collected to measure malondialdehyde (MDA), nitric oxide
(NO) metabolites, thiol, super oxide dismutase (SOD) and catalase (CAT).
Results: Scopolamine decreased the latency to enter the dark in passive avoidance
test compared to control group. It also increased MDA and NO metabolites while
decreased thiol, SOD and CAT in comparison with control group. Captopril increased
the latency to enter the dark. It also decreased MDA and NO metabolites while,
increased thiol, SOD and CAT.
Conclusion: Captopril protected brain tissues oxidative damage and improved
learning and memory impairment induced by scopolamine.
Keywords :
Scopolamine , Captopril , Oxidative stress , Learning and memory
Journal title :
Physiology and Pharmacology
