Title of article :
Effects of delta- Aminolevulinic Acid Dehydratase Gene Polymorphism on Hematological Parameters and Kidney Function of Lead-exposed Workers
Author/Authors :
Sobhi Siha, Mona Department of Occupational and Environmental Medicine - Faculty of Medicine - Cairo University, Egypt , Abdel-Hamid Shaker, Dalia Department of Occupational and Environmental Medicine - Faculty of Medicine - Cairo University, Egypt , Saad Teleb, Hebatalla Department of Occupational and Environmental Medicine - Faculty of Medicine - Cairo University, Egypt , Ahmed Rashed, Laila Department of Medical Biochemistry and Molecular Biology - Faculty of Medicine - Cairo University, Egypt
Abstract :
Lead exposure is associated with several health hazards among workers with different individual
responses. We conducted this study to determine the possible effects of lead exposure
on hematological parameters and kidney function of a group of Egyptian ammunition workers
and the interaction of aminolevulinic acid dehydratase (ALAD) G177C gene polymorphisms
as an effect modifier. Significant differences were observed between exposed workers with
ALAD1-1 and ALAD1-2 genotypes in terms of blood lead level, hematological parameters and
kidney function. It seems that δ-ALAD gene polymorphism may be an effect modifier and a
marker of genetic susceptibility to lead toxicity.
Keywords :
Explosive agents , Lead , Porphobilinogen synthase , Polymorphism , genetic , beta 2-Microglobulin
Journal title :
International Journal of Occupational and Environmental Medicine (IJOEM)
