Author/Authors :
Keske, Murat Kayseri City Hospital - Department of Urology - Kayseri, Turkey , Gök, Bahri Yildirim Beyazit University - School of Medicine - Ankara Ataturk Training and Research Hospital - Department of Urology - Ankara, Turkey , Ener, Kemal Umraniye Training and Research Hospital - Department of Urology - Istanbul, Turkey , Özcan, Muhammet Fuat Ankara Ataturk Training and Research Hospital - Department of Urology - Ankara, Turkey , Özayar, Asım Ankara Ataturk Training and Research Hospital - Department of Urology - Ankara, Turkey , Okulu, Emrah Ankara Ataturk Training and Research Hospital - Department of Urology - Ankara, Turkey , Neşelioğlu, Salim Ankara Ataturk Training and Research Hospital - Department of Biochemistry - Ankara, Turkey , Çakmak, Serdar Ordu University Training and Research Hospital - Department of Urology - Ordu, Turkey , Asil, Erem Ankara Ataturk Training and Research Hospital - Department of Urology - Ankara, Turkey , Aldemir, Mustafa Ankara Ataturk Training and Research Hospital - Department of Urology - Ankara, Turkey , Erel, Özcan Yildirim Beyazit University - School of Medicine - Ankara Ataturk Training and Research Hospital - Department of Biochemistry - Ankara, Turkey
Abstract :
Purpose: We analyzed the role of oxidative stress in detrusor overactivity (DO) by measuring serum total antioxidant
capacity (TAC), total oxidant status (TOS), binding capacity of exogenous cobalt to human albumin (IMA),
serum advanced oxidation protein products (AOPP), paraoxonase (PON), and arylesterase.
Materials and Methods: The study included 38 female patients diagnosed with DO and 29 healthy female subjects
forming the control group. Serum total antioxidant capacity (TAC), total oxidant status (TOS), binding capacity
of exogenous cobalt to human albumin (IMA), serum advanced oxidation protein products (AOPP), paraoxonase
(PON), and arylesterase were analyzed. The results of serum TAC, TOS, IMA, AOPP, PON, and arylesterase of
the subjects in both groups were compared.
Results: There was no difference between the groups in terms of age. When compared to the control group, serum
TAC and IMA levels were statisticaly lower (P < 0.001) and higher (P = 0.003), respectively. However, TOS,
AOPP, PON, arylesterase levels were similar in both groups ( P > 0.05 ).
Conclusion: There seems to be an association between DO and oxidative damage according our results, this can
be measured by analyzing TAC and IMA in this patient group.
Keywords :
detrusor overactivity , hypoxia , ischemia , oxidative stress , total antioxidant capacity
