Author/Authors :
Soo Kim, Bum Department of Urology - School of Medicine - Kyungpook National University - Daegu, Korea , Kim, Tae-Hwan Department of Urology - School of Medicine - Kyungpook National University - Daegu, Korea , Kim, Ki Ho Department of Urology - College of Medicine - Dongguk University - Gyeongju, Korea , Kim, Byung Hoon Department of Urology - College of Medicine - Keimyung University - Daegu, Korea , Ha, Ji Yong Department of Urology - College of Medicine - Keimyung University - Daegu, Korea , Cho, Deok Hyun Department of Urology - Gumi CHA Medical Center - Cha University - Gumi, Korea , Kim, Gun Nam Department of Urology - Gumi CHA Medical Center - Cha University - Gumi, Korea , Lee, Yoon Hyung Department of Urology - Daegu Fatima Hospital - Daegu, Korea , Soo Kim, Jae Department of Urology - Daegu Fatima Hospital - Daegu, Korea , Jung, Hyun-Jin Department of Urology - Daegu Catholic University Medical Center - Daegu, Korea , Shin, Hong Seok Department of Urology - Daegu Catholic University Medical Center - Daegu, Korea , Song, Phil Hyun Department of Urology - College of Medicine - Yeungnam University - Daegu, Korea , Yoon, Jong Hyun Department of Urology - Soonchunhyang University Gumi Hospital - Gumi, Korea , Kim, Jae Ho Department of Urology - Soonchunhyang University Gumi Hospital - Gumi, Korea , Yoo, Eun Sang Department of Urology - School of Medicine - Kyungpook National University - Daegu, Korea
Abstract :
Purpose: The study was designed to assess and predict patient-reported goal achievement after treatment of benign
prostatic hyperplasia (BPH) patients with tamsulosin.
Materials and methods: From November 2013 to October 2015, 272 patients initially diagnosed with BPH were
prospectively enrolled in nine different centers. Before the treatment, subjective final goals were recorded by all
patients. Every four weeks, the treatment outcomes were evaluated using international prostate symptom score
(IPSS) and uroflowmetry, and adverse events were recorded. Patient-reported goal achievements were assessed
after 12 weeks of treatment.
Results: Of the enrolled patients, 179 patients completed the study. The pretreatment patients’ goals included
the frequency improvement, nocturia improvement, residual urine sense improvement, well voiding, hesitancy
improvement, weak urine stream improvement, urgency improvement, and voiding-related discomfort improvement.
Of the 179 patients, 129 patients (72.1%) reported that they achieved their primary goals after three months
of medical therapy. Logistic regression analysis revealed that pretreatment quality of life (OR = 8.621, 95% CI:
2.154-9.834), and improvement of quality of life (OR = 6.740, 95% CI: 1.908-11.490) were independent predictors
of patient-reported goal achievement after tamsulosin monotherapy.
Conclusion: Overall patient-reported goal achievement after medical therapy for BPH was high and the scores of
pretreatment quality of life and improvement of quality of life can be important factors to predict the achievement
of treatment goals.
Keywords :
prostatic hyperplasia , adrenergic alpha-antagonists , drug therapy , lower urinary tract symptoms , patient outcome assessment
