Title of article :
Recent Advances in Targeting of Breast Cancer Stem Cells Based on Biological Concepts and Drug Delivery System Modification
Author/Authors :
Aliyari-Serej, Zeynab Department of Applied Cell Sciences - School of Advanced Medical Sciences - Tabriz University of Medical Sciences - Immunology Research Center - Tabriz University of Medical Sciences - Student Research Committee - Tabriz University of Medical Sciences , Ebrahimi, Ayyub Department of Molecular Biology and Genetics - Faculty of Arts and Sciences - Halic Uuniversity - Istanbul, Turkey , Barazvan, Balal Department of Basic Sciences - School of Medicine - Gonabad University of Medical Sciences , Iran , Ebrahimi-Kalan, Abbas Department of Neurosciences and Cognition - School of Advanced Medical Sciences - Tabriz University of Medical Sciences , Hajiasgharzadeh, Khalil Immunology Research Center - Tabriz University of Medical Sciences , Kazemi, Tohid Department of Immunology - Faculty of Medicine - Tabriz University of Medical Sciences , Baradaran, Behzad Immunology Research Center - Tabriz University of Medical Sciences - Department of Immunology - Faculty of Medicine - Tabriz University of Medical Sciences
Abstract :
Breast cancer with various biological diversity known as the common reason of death in
the world and despite progress in novel therapeutic approaches, it faced with failure and
recurrence in general. Recent clinical and preclinical statistics support cancer stem cells (CSCs)
hypothesis and its similarities with normal stem cells. Evaluation of related paper conclude in
significance finding in the further characterization of CSCs biology such as surface biomarkers,
microenvironment regulatory molecules, cell signaling pathways, cell to cell transition and
drug efflux pumps to overcome multidrug resistance and effective therapy. Emerging novel data
indicate biological concepts in the base of unsuccessful treatment. A powerful understanding
of the cell signaling pathways in cancer and CSCs topics can be led us to define and control
treatment problems in cancer. More recently nano medicine based on drug delivery system
modification and new implications on combinatorial therapy have been used to treat breast
cancer effectively. The aim of this review is focus on CSCs as a potential target of cancer therapy,
to overcome the limitation and problems of current therapeutic strategies in cancer.
Keywords :
Breast cancer , Cancer stem cells , Cell signaling , Multi-drug resistance , Nanomedicine
Journal title :
Advanced Pharmaceutical Bulletin
