Title of article :
The Correlation Between the Plasma Level of Endothelin-1 and Pulmonary Artery Pressure in Patients on Hemodialysis Due to End-Stage Renal Disease
Author/Authors :
Tavana ، Sasan Department of Internal Medicine - School of Medicine - Shahid Beheshti University of Medical Sciences , Argani ، Hasan Department of Internal Medicine - School of Medicine - Shahid Beheshti University of Medical Sciences , Khani ، Mohammad Department of Cardiology - School of Medicine - Shahid Beheshti University of Medical Sciences , Shariatmadari ، Maryam Department of Internal Medicine - School of Medicine - Shahid Beheshti University of Medical Sciences , Dabbagh ، Ali Anesthesiology Research Center - Shahid Beheshti University of Medical Sciences
Abstract :
Background: Chronic kidney disease, especially in patients with underlying pulmonary arterial hypertension (PAH), severely deteriorates the patients quality of life. Early diagnosis would help to improve the outcome. Objectives: This study was performed to assess the association between the plasma level of endothelin-1 and the measured PAH in the patients on hemodialysis due to end-stage renal disease. Patients and Methods: In a descriptive, analytic, cross-sectional study, 40 patients were recruited. The pulmonary artery pressure (PAP) was measured via echocardiography and its association with plasma endothelin-1 as well as CRP levels was assessed. Results: There was a significant association between PAP and endothelin-1 (r = 0.93; P 0.0001) as well as PAP and CRP (r = 0.893; P 0.0001). Conclusions: The study demonstrated that in patients with underlying kidney disease, pulmonary artery pressure is strongly associated with endothelin-1 levels as well as CRP.
Keywords :
Endothelin , 1 , Chronic Kidney Disease , Artery , Pressure
Journal title :
archives of critical care medicine
