Title of article :
Scaffolds in Dental Tissue Engineering: A Review
Author/Authors :
Farzin ، Ali Department of Tissue Engineering and Applied Cell Sciences - School of Advanced Technologies in Medicine, Research Center for Sciences and Technology in Medicine - Tehran University of Medical Sciences , Bahrami ، Naghmeh Department of Tissue Engineering and Applied Cell Sciences - School of Advanced Technologies in Medicine, Craniomaxillofacial Research Center - Tehran University of Medical Sciences , Mohamadnia ، Abdolreza Department of Biotechnology - Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases; School of Advanced Technologies in Medicine - Shahid Beheshti University of Medical Sciences , Mousavi ، reza College of Health Professions - Thomas Jefferson University , Gholami ، Mina Department of Biology - Islamic Azad University, Tehran Sciences and Research Branch , Ai ، Jafar Department of Tissue Engineering and Applied Cell Sciences - School of Advanced Technologies in Medicine - Tehran University of Medical Sciences , Moayeri ، Razieh Sadat Department of Endodontics - School of Dentistry - Tehran University of Medical Sciences
Abstract :
Context: The major aim of tissue engineering is inducing of the body’s mechanisms to regenerate damaged tissues to original condition and task. Scaffolds are 3D porous constructs which provide a cellular microenvironment needed for tissue engineering. Choosing a biomaterial with proper biological, physical, and mechanical properties is of great importance in tooth tissue engineering. Thus, the current study reviews the properties of different polymers and ceramics for use as scaffolds in tooth dental regeneration. Evidence Acquisition: The current study searched databases such as Elsevier, Wiley, Google Scholar, and PubMed in English from 1972 to 2018. After going through the required process, 29 articles were eventually confirmed and enrolled in this review paper. Conclusions: The results of this work confirmed that thanks to having the ability to provide suitable amounts of interconnected porosities, high ratio of surface area to volume, proper mechanical strength, and different geometries required for tissue engineering, polymers are a good option for regeneration of tooth tissues. Although bioceramics such as calcium phosphate and glasses have good biocompatibility and bioactivity, their poor mechanical properties and low degradation rate limit their extensive use in tooth tissue regeneration.
Keywords :
Dental , Tissue Engineering , Bioengineered Teeth , Scaffolds
Journal title :
Archives of Neuroscience
