Title of article :
The Role of Next Generation Sequencing in Diagnosis of Brain Tumors: A Review Study
Author/Authors :
Shirian ، Sadegh Department of Pathology - School of Veterinary Medicine - Shahrekord University , Daneshbod ، Yahya Department of Pathology and Laboratory Medicine - Loma Linda University , Jangjoo ، Saranaz School of Medicine - Shiraz University of Medical Sciences , Ghaemi ، Amir Department of Virology - Pasteur Institute of Iran , Goodarzi ، Arash Department of Tissue Engineering - School of Medicine - Fasa University of Medical Sciences , Ghavideldarestani ، Maryam Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases - Shahid Beheshti University of Medical Sciences , Emadi ، Ahmad Department of Pathology - School of Veterinary Medicine - Shahrekord University , Ai ، Arman School of Medicine - Tehran University of Medical Sciences , Ahmadi ، Akbar Department of Tissue Engineering and Applied Cell Sciences - School of Advanced Technologies in Medicine - Tehran University of Medical Sciences , Ai ، Jafar Department of Tissue Engineering and Applied Cell Sciences - School of Advanced Technologies in Medicine - Tehran University of Medical Sciences
Abstract :
Since the number of prognostic and predictive neuro-oncologic genetic markers is steadily increasing, a comprehensive analysis of the molecular techniques used to examine neuro-oncology samples is vastly required. Molecular analysis and profiling of brain malignancies result in improved diagnostic accuracy, target identification, and predictive prognosis. Application of high-throughput molecular approaches, such as next generation sequencing (NGS), to analyze brain tumors has provided a large amount of molecular information. In the clinical practice, the application of NGS has been increased, which has consequently improved the treatment option for brain cancer as well as other types of malignancies. Target therapy has recently become one of the most promising treatment options for various tumors, especially brain tumors. In this review, we provided and summarized high-throughput genomic studies, such as NGS technique, that could independently identify the integrated management and diagnosis of primary human brain tumors across a variety of entities with pathognomonic genetic alterations.
Keywords :
Next , Generation Sequencing , Brain Tumors , Target Identification , Genetic Markers
Journal title :
Archives of Neuroscience
