Title of article :
A Mitochondrial Disorder in a Middle Age Iranian Patient: Report of a Rare Case
Author/Authors :
Almasi ، Mostafa Department of Neurology - Firoozgar Hospital - Iran University of Medical Sciences , Motamed ، Mohammad Reza Department of Neurology - Firoozgar Hospital - Iran University of Medical Sciences , Mehrpour ، Masoud Department of Neurology - Firoozgar Hospital - Iran University of Medical Sciences , Haghi-Ashtiani ، Bahram Department of Neurology - Firoozgar Hospital - Iran University of Medical Sciences , Haji Akhondi ، Fahimeh Department of Neurology - Firoozgar Hospital - Iran University of Medical Sciences , Nilipour ، Yalda Mofid Children Hospital, Pediatric Pathology Research Center - Shahid Beheshti University of Medical Sciences , Fereshtehnejad ، Seyed-Mohammad Department of Neurobiology - Care Sciences and Society, Karolinska Institutet
Abstract :
Introduction: Mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) can involve multiple systems and cause stroke-like episodes and status epilepticus. Case Presentation: A 48-year-old female with history of early fatigability, migraine-type headaches, and bilateral sensory-neural hearing loss presented 3 episodes of serial seizures. On admission she was affected by Wernicke aphasia and, then, right hemiparesis. Investigations showed elevated arterial lactate and ragged red fibers on muscle biopsy. Conclusion: Though more commonly diagnosed during childhood, some cases of adult-onset MELAS syndrome are reported. This syndrome should be considered in patients with stroke-like events in adults without cerebrovascular risk factors and difficult-to-treat seizures.
Keywords :
Mitochondrial disorder , MELAS Syndrome , Middle age
Journal title :
Basic and Clinical Neuroscience
