Title of article :
GO/TiO2 Hybrid Nanoparticles as New Photosensitizers in Photodynamic Therapy of A375 Melanoma Cancer Cells
Author/Authors :
Karbalaei, Atieh Department of Molecular Medicine - Institute of Medical Biotechnology - National Institute for Genetic Engineering and Biotechnology, Tehran , Mohammadalipour, Zahra Department of Molecular Medicine - Institute of Medical Biotechnology - National Institute for Genetic Engineering and Biotechnology, Tehran , Rahmati, Marveh Cancer Biology Research Canter - Tehran University of Medical Sciences , Khataee, Alireza Research Laboratory of AdvancedWater andWastewater Treatment Processes - Department of Applied Chemistry - Faculty of Chemistry - University of Tabriz , Moosavi, Mohammad Amin Department of Molecular Medicine - Institute of Medical Biotechnology - National Institute for Genetic Engineering and Biotechnology, Tehran
Abstract :
Photodynamic therapy (PDT) by nanoparticles (NPs) has been proposed as a new emerging therapeutic approach for the treatment
of melanoma. In this study, the researchers investigate potential of photodynamic graphene oxide (GO)/TiO2 hybrid (GOT) NPs as
new photosensitizers (PSs) in A375 melanoma cancer cell line. The results showed that while different concentrations of GOT NPs (1
- 100 g/mL) were inert, their irradiation with visible-light induced growth arrest and cell death in A375 cells in a dose-despondent
manner. These anti-cancer effects were accompanied by significant morphological changes, suggesting GOT NPs have a potential
for further evaluation as new generation of PSs for cancer therapy.
Keywords :
A375 Cells , Graphene Oxide/Titanium Dioxide , Melanoma , Photodynamic Therapy
Journal title :
Journal of Skin and Stem Cell
