Title of article :
Dermal Fibroblast Cells: Biology and Function in Skin Regeneration
Author/Authors :
Nilforoushzadeh, Mohammad Ali Skin and Stem Cell Research Center - Tehran University of Medical Sciences , Ahmadi Ashtiani, Hamid Reza Department of Basic Sciences - Faculty of Pharmacy - Pharmaceutical Sciences Branch - Islamic Azad University (IAUPS), Tehran , Jaffary, Fariba Skin Diseases and Leishmaniasis Research Center - Isfahan University of Medical Sciences , Jahangiri, Faeze Skin and Stem Cell Research Center - Tehran University of Medical Sciences , Nikkhah, Nahid Skin and Stem Cell Research Center - Tehran University of Medical Sciences , Mahmoudbeyk, Mona Skin and Stem Cell Research Center - Tehran University of Medical Sciences , Fard, Maryam Skin and Stem Cell Research Center - Tehran University of Medical Sciences , Ansari, ZibaJaber Skin and Stem Cell Research Center - Tehran University of Medical Sciences , Zare, Sona Department of Biology - Faculty of Basic Science - Islamic Azad University - Hamedan Branch, Hamedan
Abstract :
Fibroblasts are mesenchymal cells, which play an important role in epithelial-mesenchymal reactions. These cells also play a key
role in epidermal proliferation and differentiation and cellular matrix formation through secretion of different growth factors and
cytokines. Cell therapy is a new treatment for skin diseases. In fact, conditions, such as burns, diabetic wounds, scars, and aging
skin, have been treated with these cells. In cell therapy, samples obtained from the patient’s skin are isolated and cultured; then,
the cells are injected into damaged tissues. In recent years, several clinical trials have been conducted in this area, and numerous
studies have been published. In this review, we aimed to investigate the biology and function of these cells in the treatment of skin
diseases.
Keywords :
Fibroblast Cells , Cell Therapy , Scar , Wound , Rejuvenation
Journal title :
Journal of Skin and Stem Cell
