Title of article :
Critical Roles of Non-coding RNAs in Acute Lymphoblastic Leukemia
Author/Authors :
Mazloumi Gavgani ، Maryam Department of Molecular Genetics - Islamic Azad University, Ahar Branch , Nargesian ، Mansooreh Young Researchers and Elite Club - Islamic Azad University, Ahar Branch , Ghorbian ، Saeid Department of Molecular Genetics - Islamic Azad University, Ahar Branch
Abstract :
MicroRNA (miRNA) is one of the noncoding RNA (ncRNA) molecules with 21 25nucleotide length, playing an important role in gene control by transcriptional gene regulation, chromatin remodeling, genetic imprinting, and translation initiation. The deregulation of ncRNA can lead to several hematopoietic malignancies such as acute lymphoblastic leukemia (ALL). The study aimed to draw the crucial features of miRNA in the pathogenesis of ALL. The findings showed that miRNA expression changes in ALL are typical and involve several signaling pathways. The variations in miRNA gene expression can lead to the incomplete expression of oncoprotein or tumor suppressor gene (TSG). It seems that ncRNAs play pivotal roles in the ALL pathogenesis. However, ncRNAs might be interested as potential diagnostic and prognostic biomarkers in ALL.
Keywords :
ncRNA , miRNA , ALL , Acute Lymphoblastic Leukemia
Journal title :
Gene Cell Tissue
Journal title :
Gene Cell Tissue
