Author/Authors :
Atefi, Najmosadat Iran University of Medical Sciences, Tehran , Nabavi, Mohammad Iran University of Medical Sciences, Tehran , Esmaeeli, Shooka Iran University of Medical Sciences, Tehran , Azizian, Zahra Iran University of Medical Sciences, Tehran , Mohagheghian, Hadi Iran University of Medical Sciences, Tehran , Javadinia, Shima Tehran University of Medical Sciences
Abstract :
Background: Treatment of some fungi species would result in the improvement of atopic eczema.
Objectives: In this study, the anti-Malassezia IgE in patients with atopic eczema before and after treatment with a ketoconazole
shampoo was determined.
Methods: In this before-after investigation, 20consecutive patients with atopic dermatitis referring to a teaching hospital in Tehran,
Iran, in 2015 were enrolled. A ketoconazole shampoo was administered two times a week each time for 5 - 10 minutes. The treatment
was used for two months and monthly evaluations were done. The total IgE level and anti-Malassezia IgE were compared at the
beginning and the end of the study.
Results: The results demonstrated that there was a statistically significant difference in the total Ig-E level and anti-Malassezia IgE
before and after treatment with ketoconazole.
Conclusions: According to the obtained results in this study, it may be concluded that ketoconazole would result in decreased
anti-Malassezia IgE and total IgE level in patients with atopic eczema.
