Title of article :
Apoptosis in Hair and Skin: A Review
Author/Authors :
Ahmadi Ashtiani, Hamid Reza Department of Basic Sciences - Faculty of Pharmacy - Pharmaceutical Sciences Branch - Islamic Azad University, Tehran , Zakizadeh, Samin Department of Basic Sciences - Faculty of Pharmacy - Pharmaceutical Sciences Branch - Islamic Azad University, Tehran , Khanahmadi, Maryam Department of Basic Sciences - Faculty of Pharmacy - Pharmaceutical Sciences Branch - Islamic Azad University, Tehran , Nilforoushzadeh, Mohammad Ali Skin and Stem Cell Research Center - Tehran University of Medical Science , Zare, Sona Skin and Stem Cell Research Center - Tehran University of Medical Science - Department of Biology - Faculty of Basic Science - Islamic Azad University - Hamedan branch
Abstract :
Context: The current study aimed at evaluating the role of apoptosis in hair and skin conditions.
Evidence Acquisition: In the current study, the role of apoptosis in the occurrence or treatment of the apoptosis-associated disease
was investigated. Likewise, the mechanism of apoptosis pathways occurring in the skin and hair cells was also reviewed.
Conclusions: Melanocyte and follicular epithelial cells are the most sensitive cells to apoptosis, whereas dermal papilla cells, fibroblasts,
and some of keratinocytes are the most resistance cells to apoptosis. According to the current review study, novel drugs
can be designed based on stimulation or inhibition of the apoptosis such as BCL2, p53 and caspase inhibitors.
Keywords :
Apoptosis , Skin , Hair , Fibroblast , Melanocyte , Keratinocyte
Journal title :
Journal of Skin and Stem Cell
