Bilateral Dentigerous Cysts in a Non-Syndromic Patient: Literature Review and Report of a Case

Introduction: Dentigerous cysts (DCs) are the most common developmental cysts of the jaws, mostly associated with impacted third molars and canines. Multiple or bilateral DCs are rare and typically occur in association with some syndromes including cleidocranial dysplasia and Gorlin-Goltz. The occurrence of multiple DCs is rare in the absence of these syndromes. Case Presentation: A 28-year-old male was referred for pain and mobility of the left mandibular second molar. On radiological examination, follicular enlargement in relation to the unerupted third molar was found. Another unilocular radiolucent area was seen in relation to the right-side unerupted third molar. A provisional diagnosis of multiple odontogenic keratocysts was made; however, the histopathological studies revealed DC on both sides. The patient’s medical history was non-significant, and no associated syndromes were present. Bilateral DCs are rare in the absence of a syndrome, and to date, only 53 cases have been reported in the literature. Here, we report the unusual bilateral occurrence of DCs associated with unerupted mandibular third molars in a non-syndromic patient with a review of the literature for this unusual finding. The one-year follow-up radiograph of the patient showed a favorable osseous formation with no evidence of recurrence of the cysts. Conclusion: A comprehensive radiographic examination, especially for mandibular third molars, is essential for correct diagnosis and management of the lesions. Furthermore, systematic clinical examinations should be performed to rule out any associated syndrome.