A Comparative Matched Study of Breast-Conserving Therapy and Modified Radical Mastectomy in Iranian Women

Background]Breast cancer is the most frequent diagnosed visceral cancer with 13400 new cases annually among Iranian women. Modified radical mastectomy (MRM) was the old standard surgical treatment in patients with breast cancer from 70 years ago and breastconserving surgery (BCS) with adjuvant radiotherapy was the standard treatment from 30 years ago.[Objectives]In this matched historical cohort study, we compared two types of therapy for breast carcinoma: breastconserving therapy (BCT), and MRM.[Methods]Medical records of 6000 patients with breast cancer from the database of Cancer Research Center of Shahid Beheshti University of Medical Sciences were reviewed and 1310 patients who had been treated by BCT (group A) or MRM (group B) were selected based on a time stratified 1:1 between September 2002 and December 2014 as 10 baseline variables. By logrank test analysis, their local recurrence (LR), disease free survival (DFS) and overall survival (OS) were evaluated and compared.[Results]In groups A and B, the median age at the diagnosis time was 48.11 and 48.64 years old, respectively. Median followup time was 71 months since April 2015. 1.68% of patients in group A and 1.07% of patients in group B had local recurrence during the five years of follow up, (P = 0.173). In the group A and B, five years DFS were 87.94% and 80.46%, (P lt; 0.001) and five years OS were 89.31% and 83.02%, respectively (P = 0.041).[Conclusions]The findings of this study showed that 5year DFS and 5year OS in BCT group were better than in the MRM group. Longer followup time of the patients to compare 10year DFS and 10year OS or even 20year OS between two groups is recommended.