Title of article :
IL-8 MayBethe Target of Arsenic in HumanBreast Milk
Author/Authors :
Ghorban ، Khodayar Department of Immunology - Faculty of Medicine - AJA University of Medical Sciences , Dadmanesh ، Maryam Department of Infectious Diseases - Faculty of Medicine - AJA University of Medical Sciences , Sheikhfathollahi ، Mahmood Department of Epidemiology and Biostatistics - Immunology of Infectious Diseases Research Center, Faculty of Medicine - Rafsanjan University of Medical Sciences , Rezai ، Zeynab Department of Food Hygiene and Safety - Faculty of Health - Shahid Sadoughi University of Medical Sciences , Ezati ، Paria Department of Food Hygiene and Safety - Faculty of Health - Shahid Sadoughi University of Medical Sciences , Salmani ، Mohammad Hossein Department of Environmental Health Engineering - Faculty of Health - Shahid Sadoughi University of Medical Sciences , Akrami Mohajeri ، Fatemeh Department of Food Hygiene and Safety - Faculty of Health - Shahid Sadoughi University of Medical Sciences , Yousefi-Daredor ، Hasan Immunology of Infectious Diseases Research Center - Rafsanjan University of Medical Sciences , Ebrahimi ، Hasan Department of Microbiology - Immunology of Infectious Diseases Research Center, Faculty of Medicine - Rafsanjan University of Medical Sciences , Kennedy ، Derek School of Biomolecular and Physical Science, Eskitis Institute for Drug Discovery - Griffith University Nathan , Kazemi Arababadi ، Mohammad Department of Immunology - Immunology of Infectious Diseases Research Center, Faculty of Medicine - Rafsanjan University of Medical Sciences
Abstract :
Background and Aims:The criticalaim of this study was to evaluate the effects of breast-milk contamination with Nickel and Arsenic, as well as aflatoxin M1 (AFM1) on the milk levels of IL-6 and IL-8. Materialsand Methods: Breast milk was collected from 76 mothers on the 30thday post-parturition and milk levels of AFM1, Nickel, Arsenic, IL-6 and IL-8 were evaluated.Results: The results showed 8 and 29 outof 76collected samples beingcontaminated with AFM1, Nickel and Arsenic, respectively. Levels of IL-6 and IL-8 in the milk samples did not differ inAFM1 and Nickel and Arsenic contaminated milk comparedwith thenormal controls (non-contaminated milks). There was a moderate positive relation between milk levels of IL-8 and Arsenic.Conclusions: Although AFM1, Nickel and Arsenic are the inducers of cytokine production;they are unable to induce secretion of IL-6 in breast milk. Arsenic can be atriggerof IL-8, which is a strong chemoattract for neutrophils. Thus, it appears that Arsenic may induce an inflammation in milk in IL-8 dependent manner.
Keywords :
Aflatoxin M1 , Arsenic , IL , 6 , IL , 8 , Nickel
Journal title :
International Journal of Medical Laboratory
Journal title :
International Journal of Medical Laboratory
