Title of article :
The Relationship Between Polymorphisms of Glutathione S-Transferase (GSTM1, GSTT1) Gene and Type 2 Diabetes Mellitus in Western Iran
Author/Authors :
Kazemisafa ، Fatemeh Health Department - Kermanshah University of Medical Sciences , Jadidian ، Kamalaldin Health Department - Kermanshah University of Medical Sciences , Rahimi ، Zohreh Medical Biology Research Center - Kermanshah University of Medical Sciences , Nomani ، Hamid Medical Biology Research Center - Kermanshah University of Medical Sciences , Ghanbari ، Azadeh Health Department - Kermanshah University of Medical Sciences , Saeb ، Gelareh Health Department - Kermanshah University of Medical Sciences , Alikhani ، Arash Health Department - Kermanshah University of Medical Sciences
Abstract :
Background: Diabetes is a chronic metabolic disorder that causes many complications in the body. Oxidative free radicals affect human beta cells. Glutathione S-transferases (GSTs) can deactivate substances formed in oxidative stress. Objectives: The present study was conducted to examine the relationship between GSTs polymorphisms and type 2 diabetes mellitus (T2DM), and to investigate the presence of GSTM1 and T1 genotypes in 176 T2DM patients and 174 healthy cases as controls. Methods: Multiplex PCR was used to confirm the presence or absence of GSTT1 and M1 genotypes. Conclusions: The obtained results indicated that the polymorphism of GSTM1 and GSTT1 does not affect the prevalence of T2DM in the study population.
Keywords :
Glutathione S , Transferase , Genetic Polymorphism , Oxidative Stress , T2DM
Journal title :
Journal of Kermanshah University of Medical Sciences
Journal title :
Journal of Kermanshah University of Medical Sciences
