Title of article :
Vaccine Design Based on Live Attenuated Cells of Toxoplasma gondii: a Review
Author/Authors :
Cheraghipour ، Kourosh Razi Herbal Medicines Research Center - Lorestan University of Medical Sciences , Mohaghegh ، Mohammad Ali Department of Laboratory Sciences - Torbat Heydariyeh University of Medical Sciences , Mardanshah ، Omid Department of Laboratory Sciences - Sirjan Faculty of Medical Sciences , Koshki ، Javad Lorestan Provincial Veterinary Service , Moradpour ، Kobra Razi Herbal Medicines Research Center - Lorestan University of Medical Sciences , Pestechian ، Nader Department of Parasitology and Mycology - School of Medicine - Isfahan University of Medical Sciences , Akhtari ، Javad Department of Medical Nanotechnology - School of Advanced Technologies in Medicine, Immunogenetics Research Center - Mazandaran University of Medical Sciences , Marzban ، Abdolrazagh Razi Herbal Medicines Research Center - Lorestan University of Medical Sciences
Abstract :
Toxoplasma gondii (T. gondii) is a well-known, commonly found pathogen by high proliferative activity in nucleated cells. This parasite has infected nearly one-third of the world’s population. Infection can result in chorioretinitis in immunocompetent hosts, encephalitis in HIV/AIDS positive patients and spontaneous abortion or neonatal death in fetuses infected with congenital toxoplasmosis. Development of vaccines for toxoplasmosis is of major importance for reducing routes of disease transmission among various host species in the world. Live attenuated vaccines resemble natural infectious agents very closely. Therefore, these vaccines are good enhancers of the immune system, often imparting lifelong immunity with only one or two doses. In this study, we review the current status of live attenuated vaccine development for Toxoplasma infection.
Keywords :
Bradyzoite , Live attenuated vaccines , Tachyzoite , Toxoplasma gondii
Journal title :
Research in Molecular Medicine
Journal title :
Research in Molecular Medicine
