Management of High Disease Activity in Multiple Sclerosis Using ZytuxTM (Rituximab, AryoGen Pharmed): Evidence from a Case Report

Rituximab is an anti-CD20 monoclonal antibody, which is used for the treatment of various autoimmune diseases. Owing to its marked effect on B cells, rituximab has also been used in the treatment of fulminant multiple sclerosis. The present study aimed to describe the case of a patient with fulminant radiological presentation, which was effectively controlled using rituximab. A 21-year-old woman initially presented with vertigo, which resolved spontaneously. The MRI indicated extensive periventricular involvement with multiple enhancing lesions. The patient was hospitalized and received pulse methylprednisolone (1 g) daily for five days. Afterwards, she was administered with ZytuxTM (1 g; rituximab, AryoGen Pharmed) for two weeks.