Title of article :
Synthesis of 2-Amino-3,5-dicarbonitrile-6-thiopyridines Using Silica-bonded N-Propyldiethylenetriamine as a Heterogeneous Solid Base Catalyst
Author/Authors :
Niknam, Khodabakhsh Persian Gulf University , Hosseini, Alireza Persian Gulf University
Abstract :
Silica-bonded N-propyldiethylenetriamine (7) is employed as a recyclable heterogeneous solid base catalyst for the synthesis of 2-amino-3,5-dicarbonitrile-6-thiopyridines through pseudo four-component condensation reaction between aromatic aldehydes, malononitrile, and 2-amino-thiophenol in refluxing ethanol. Silica-bonded N-propyldiethylenetriamine showed much the same efficiency when used in consecutive reaction runs.
Keywords :
2-Amino-3 , 5-dicarbonitrile-6-thiopyridines , Heterogeneous catalysts , Solid bases , Synthesis , Multi-component reactions
Journal title :
Organic Chemistry Research
