Title of article :
Synthesis of Furo[2,3-d]pyrimidine-2,4(1H,3H)-diones From Alcohols Using T3P/DMSO
Author/Authors :
Soleimani, Ebrahim Department of Chemistry - Razi University , Khodaei, Mohammad Mehdi Department of Chemistry - Razi University , Yazdani, Hossein Department of Chemistry - Razi University , Mohammad Nejhad, Jafar Department of Chemistry ShahreQods Branch - Islamic Azad University , Tehran
Abstract :
T3P/DMSO is shown to be an effective and mild reagent for the one-pot synthesis of furo[2,3-d]pyrimidine-2,4(1H,3H)-diones from a variety of alcohols. Alcohols are oxidized in situ to aldehydes under mild conditions, which undergo a three-component reaction with N,N'-dimethylbarbituric acid and various isocyanides to afford furo[2,3-d]pyrimidine-2,4(1H,3H)-diones in good yields.
Keywords :
Furo[2 3-d]pyrimidine , T3P/DMSO , Oxidization , Isocyanide
Journal title :
Organic Chemistry Research
