Significance of Cardiac Troponin I Elevation in Traumatic Brain Injury Patients

Background: Myocardial dysfunction is frequently described as an underlying cause of mortality in traumatic brain injury (TBI) known as brain-cardiac link. However the impact on prognosis of a disease remains uncertain. Objectives: The current study aimed at investigating the correlation between TBI and cardiac troponin I (cTnI) rise and in-hospital mortality rate among patients with TBI. Methods: In the current prospective study TBI patients with abbreviated injury scale score (AIS) 3 and Glasgow coma scale (GCS) score≤8 with cTnI measurement within the first 24 hours of admission were evaluated. Chi-square, Kruskal-Wallis, Mann-Whitney U and Logistic Regression tests were used for data analysis. Results: A total of 166 eligible patients were studied .The mean age of the cases was 37.64±17.21 years, largely under 65 (93.4%) and male (86.7%).The most common injuries were cerebral contusion (35.1%), while motor vehicle crash (MVC) was the most common cause of injuries (83.73%); 59 % of the patients showed detectable cTnI concentrations within 24 hours of admission; 65.7% of the patients expired; they showed higher levels of cTnI compared to survivors that showed lower levels, 0.148 0.074 vs 0.057±0.055, respectively (P 0.001). Moreover, a significant association was observed between mortality rate and lower admission GCS 3.49± 1.08 vs 6.79±1.66, respectively (P 0.001). Conclusions: Increased cTnI levels could be a predictor of mortality among patients with TBI. Its measurement and investigation for therapeutic strategies could lead to better management of these cases.