Title of article :
Evaluation of the Potential Antioxidant Role of High-Density Lipoprotein-Cholesterol (HDL-C) in Patients with Ulcerative Colitis
Author/Authors :
Vaghari Tabari ، Mostafa Department of Biochemistry - Molecular Medicine Research Center, Hormozgan Health Institute, Faculty of Medicine - Hormozgan University of Medical Sciences , Moein ، Soheila Department of Biochemistry - Molecular Medicine Research Center, Hormozgan Health Institute, Faculty of Medicine - Hormozgan University of Medical Sciences , Qujeq ، Durdi Department of Clinical Biochemistry - Health Research Institute, Cellular and Molecular Biology Research Center (CMBRC) - Babol University of Medical Sciences , Kashifard ، Mehrdad Department of Internal Medicine, Gastroenterology Division - Ayatollah Rouhani Hospital - Babol University of Medical Sciences , Shokri Shirvani ، Javaad Department of Internal Medicine, Gastroenterology Division - Ayatollah Rouhani Hospital - Babol University of Medical Sciences , Hajian Tilaki ، Karimollah Departments of Biostatistics and Epidemiology - Babol University of Medical Sciences , Farshidfar ، Gholamreza Department of Biochemistry - Faculty of Medicine - Hormozgan University of Medical Sciences
Abstract :
Background: Ulcerative colitis is acommontype of inflammatory bowel disease (IBD). The aim of the present study was to examine the relationship between lipid profile, especially high-density lipoprotein (HDL), and malondialdehyde (MDA) level in patients with ulcerative colitis. Methods: In this study, 45 patients with ulcerative colitis were selected, 25 of whom were diagnosed with active disease and 20 were in clinical remission. Moreover, 45 healthy subjects were selected as the controls. The status of serum lipid profile and MDA level were measured via precise photometric methods. The obtained data were analyzed, using independent t-test and correlation coefficient test. P 0.05 was considered statistically significant. Results: The serum level of HDL-C decreased, while the serum level of MDA significantly increased in patients with ulcerative colitis in comparison with the healthy controls (P 0.05). No significant correlation was observed between the MDAlevel and triglyceride, cholesterol, and LDL-C levels in patients with ulcerative colitis. However, a significant inverse correlation was observed between HDL-C and MDA levels (r, -0.306; P 0.05). Conclusions: The inverse correlation between HDL-C andMDAlevels can be regarded as an indicator of the protective role of HDL-C against lipid peroxidation in ulcerative colitis. In patients with ulcerative colitis, the serum level of HDL-C decreased in comparison with healthy subjects. Therefore, it is necessary to determine the HDL-C level in patients with ulcerative colitis.
Keywords :
Ulcerative Colitis Disease , HDL , C Level , MDA Level , Active and Inactive Disease
Journal title :
Annals of Colorectal Research
Journal title :
Annals of Colorectal Research
