Title of article :
Comparison of Difference Between Fluconazole and Silver Nanoparticles in Antimicrobial Effect on Fluconazole-Resistant Candida Albicans Strains
Author/Authors :
Alimehr ، Shadi Department of Medical Parasitology and Mycology - School of Public Health - Tehran University of Medical Sciences , Shekari Ebrahim Abad ، Hamide Pediatric Infections Research Center, Mofid Children’s Hospital - Shahid Beheshti University of Medical Sciences , Shahverdi ، Ahmadreza Faculty of Pharmacy, Pharmaceutical Sciences Research Center - Tehran University of Medical Sciences , Hashemi ، Jamal Department of Medical Parasitology and Mycology - School of Public Health - Tehran University of Medical Sciences , Zomorodian ، Kamyar Department of Parasitology and Mycology - School of Medicine - Shiraz University of Medical Sciences , Moazeni ، Maryam Department of Medical Mycology - School of Medicine - Mazandaran University of Medical Sciences , Vosoghian ، Sahar Pediatric Infections Research Center, Mofid Children’s Hospital - Shahid Beheshti University of Medical Sciences , Rezaie ، Sassan Department of Medical Parasitology and Mycology - School of Public Health - Tehran University of Medical Sciences
Abstract :
Background: Opportunistic fungi cause fungal infections. Whereas some microorganisms are resistant to chemical drugs, scientists are looking for new natural and inorganic antimicrobial agents. The recent research on metal nanoparticles showed that silver nanoparticles (nanosilver) exhibits lower toxicity to mammalian cells and higher toxicity to microorganisms. Objectives: This study aimed to compare the difference between antimicrobial effect of nanosilver and some antibiotic agents on Candida albicans. Materials and Methods: We studied effect of fluconazole, nanosilver, and their combination on 20 fluconazole-resistant C. albicans from two centers and one standard sample (ATCC10261) by minimal inhibitory concentration (MIC) method. Results: Result of fungi static and fungicidal activities of nanosilver plus fluconazole on fluconazole-resistant C. albicans showed better inhibitory effect on the growth of standard C. albicans when MIC of fluconazole (8 µg/mL) combined with MIC of Nanosilver (0.0625 µg/ mL). Conclusions: Totally, our results showed nanosilver caused an increase of at least nine-fold in inhibitory effect of fluconazole.
Keywords :
Fluconazole , Silver , Nanoparticles , Candida albicans
Journal title :
Archives of Pediatric Infectious Diseases
Journal title :
Archives of Pediatric Infectious Diseases
