Evaluation of Toxicity of Engine oil Enriched with Copper Nanoparticles and its Impact on Pathology of Intestinal, Liver, Lung and Kidney Tissues

Objective(s): Iranian researchers have enriched conventional engine oil with nanoparticles at the Institute of Petroleum Research and hope that this product can replace conventional engine oil due to the improved effects of copper nanoparticles on oils. the purpose of this study was to investigate the pathological effect of engine oil enriched with copper nanoparticles on the rat. Methods: In this study, 72 female rat were randomly divided into 8 experimental groups, and three treatment groups (repeated) oral doses of 2000 mg /kg and 5000 mg /kg engine oil containing and without copper nanoparticles in three treatment groups at 30 minutes, 4 hours and 24 hours. Results: In treatment group A and B, oral dose of 5000 mg/kg engine oil containing and without copper nanoparticles showed a significant positive correlation with lethality at 30 minutes, 4 hours and 24 hours. p 0.001). Also in treatment group C, oral dose of 5000 mg/kg engine oil without copper nano particle showed a positive and significant correlation with lethality in 24 hours (p 0.001). Severe hypertension in the cortex and medulla of the kidney, severe hepatocyte swelling, severe hyperemia in the alveolar wall, anaplasmosis like changes and changes in the depth of the intestinal crypts, Were the most important observations of the pathological sections of different tissues at the engine dose of mg /kg. Contains copper nanoparticles. Conclusions: The results of this study showed that the toxic effects of engine oil containing copper nanoparticles were no more than those of engine oil without copper nanoparticles.