Author/Authors :
Hashemi ، Masoud Department of Anesthesiology and Pain Medicine - Faculty of Medicine - Shahid Beheshti University of Medical Sciences , Moradi ، Siamak Shohadaye-Tajrish Hospital - Shahid Beheshti University of Medical Sciences , Taheri ، Mehrdad Department of Anesthesiology and Pain Medicine - Faculty of Medicine - Shahid Beheshti University of Medical Sciences , Momenzadeh ، Siroos Department of Anesthesiology and Pain Medicine - Faculty of Medicine - Shahid Beheshti University of Medical Sciences , Shoae-Hassani ، Alireza Applied Cell Sciences (Cell Therapy) Department - School of Advanced Technologies in Medicine - Tehran University of Medical Sciences , Ghamari ، Ali Department of Cell and Molecular Biology - Faculty of Life Sciences - Islamic Azad University, North Tehran Branch , Hassani ، Hasti Department of Anesthesiology and Pain Medicine - Faculty of Medicine - Shahid Beheshti University of Medical Sciences , Ghasemi ، Mahshid Anesthesiology Research Center, Taleghani Hospital - Shahid Beheshti University of Medical Sciences , Solhpour ، Ali Anesthesiology Research Center, Taleghani Hospital - Shahid Beheshti University of Medical Sciences , Dadkhah ، Payman Department of Anesthesiology and Pain Medicine - Faculty of Medicine, Anesthesiology Research Center - Shahid Beheshti University of Medical Sciences
Abstract :
Background: Discogenic low back pain is one of the leading causes of pain and disability across the world. A growing interest in the area of regenerative medicine, led by an improved understanding of the role of mesenchymal stem cells in tissue homeostasis and repair. Cases Report: We had two patients suffered from chronic discogenic low back pain. They were underwent injection of intra-discal 1.5 cc of Adipose Derived Mesenchymal Stem Cells (ADMSC) and followed up for 6 months. After this period of time, there was a significant reduction in both VAS and ODI scores in patients. Conclusion: These data warrant further studies so that we can enhance our understanding of the other unknown mechanisms, which may exist behind stem cell injection. If the effectiveness of such injection to reduce pain and improve function is shown in the upcoming studies, it may provide a new insight for increasing this method of treatment as a proper option in the near future.
