Effects of Quercetin Supplementation on Oxidative Stress, Blood Pressure, Aerobic Power, Concentric Pathologic Hypertrophy and Cardiac Function in Men with Hypertension and Coronary Artery Disease After Percutaneous Coronary Intervention: a Randomized, Double-Blind Placebo-Controlled Trial

Background and Objectives: The aim of this study was to investigate possible effects of quercetin supplementation on oxidative stress, blood pressure, aerobic power, concentric pathologic hypertrophy and cardiac function in men with hypertension and coronary artery disease (CAD) after percutaneous coronary intervention (PCI). Materials and Methods: The present study was a randomized, doubleblind clinical trial; in which, 24 men with hypertension and CAD after PCI (aged 40 -60 years) were participated. Patients were prescribed quercetin (250 mg/day) or placebo for two months. Plasma total antioxidant capacity (TAC) and malondialdehyde (MDA) were assessed using colorimetric methods as well as left ventricular diastolic dysfunction (LVDD), p wave depression (PWD), ejection fraction (EF) and E/A using echocardiography and WRp using StorerDavise cycle test. Systolic and diastolic blood pressures were measured before and after the intervention. Data were analyzed using ANCOVA and pairedsample Ttest. Results: Supplementation resulted in a significant improvement in oxidative stress reduction (TAC increased and MDA decreased), systolic and diastolic blood pressures, systolic (EF) and diastolic (E/A) functions and aerobic power, compared to pretest and placebo groups following eight weeks of treatment (p thinsp; thinsp;0.05). A small decrease in RWT was seen in quercetin group at the end of intervention with no statistical significance (p 0.05). The RWT was not significantly different between the quercetin and placebo groups (p 0.05). Conclusions: Quercetin supplementation can improve oxidative stress, blood pressure, left ventricular function and aerobic power in men with hypertension and CAD after PCI. However, this includes no effects on concentric pathologic hypertrophy. Further studies are necessary to verify effects of quercetin supplementation on left ventricular hypertrophy in humans.