Title of article :
The Role of Signaling Pathway on Osteoprogenitor Cell Behavior and Bone Formation
Author/Authors :
Hashemi ، Maedeh Anatomy Department - School of Medicine - Shiraz University of Medical Sciences , Shakeri ، Vahid Department of Orthopedic - Arak University of Medical Sciences , Mosallaei ، Haleh Iran University of Medical Sciences , Kholdebarin ، Mona Islamic Azad University, Science and Research Branch , Bakhtiari ، Mohamad Anatomy Department - School of Medicine - Isfahan University of Medical Sciences , Mohamadpour ، Masoomeh Neuroscience Research Center, School of Advanced Medical Sciences and Technologies - Iran University of Medical Sciences , Gholami ، Saeed Iran University of Medical Sciences , Yazdanparast ، Amir Mycology Department - School of Allied Medicine - Iran University of Medical Sciences
Abstract :
Different biomarkers and signaling pathways are involved in bone development. These factors lead to different osteoprogenitor cell reactions. Proliferation, migration, and differentiation of osteoprogenitor cells is induced by different intracellular and extracellular molecular signaling pathways. As mesenchymal stem cells (MSCs) and their differentiation during repair and development of bone processes have significant roles, it is believed that sensible molecular signaling pathways involvement is vital to the development of bone formation, bone substitute materials, and bone repair. This study reviews various keys of signaling pathway that terminate proliferation, migration, and differentiation of osteoprogenitor cells.
Keywords :
Bone , Signaling Pathways , Osteoprogenitor , Proliferation , Differentiation
Journal title :
Thrita Student Journal of Medical Sciences
Journal title :
Thrita Student Journal of Medical Sciences
