Marine natural products with anti-inflammation effects

The ocean possesses a complex setting with high pressure, high salinity, oligotrophy, low temperature and weak illumination conditions. To survive and evolve in such harsh surroundings, marine organisms metabolize a series of chemicals known as secondary metabolites which indicate structural and functional diversity to adapt interspecific survival competition. During recent decades, the antiinflammatory property of marine natural products has come under scrutiny as inflammation involves in the vast majority of diseases. Correspondingly, a myriad of marine bioactive molecules including terpenes, polypeptides, polysaccharides, sterols and many others may bring a new insight into inflammation therapies with multifarious sources and minimal side effects. And a better understanding of their mechanisms of antiinflammation may lead to better treatments for numerous diseases. Herein, the research progress of marinederived antiinflammation compounds and the relevant mechanisms were reviewed, to provide a basis for the research and development of antiinflammatory marine drugs.