Hypoglycemic Effects of Nigella Sativa Extract and Endurance Training in Streptozotocin Induced Diabetic Rats

Objective: Diabetes is a common disease and its prevalence rate is rapidly increasing. Aim of present study was to review the hypoglycemic effects of Nigella sativa (N.sativa) extract and endurance training in streptozotocin induced diabetic rats. Materials and Methods: In this experimental research from 50 streptozotocine induced diabetic rats, 32 rats with more than 300 mg/dL fasting blood glucose (FBS) selected and divided into four groups of 8 rats (1) endurance training, (2) N.sativa extract, (3) N.sativa extract with endurance training, and (4) control. Groups 1 and 3 trained endurance exercise 4 weeks, 5 sessions per week. Two and 3 groups received 4 weeks intraperitoneal 100 mg/kg N.sativa extract daily. For statistical analysis of data used Kolmogorov– Smirnov test, one way ANOVA and tukey post hoc tests. P-value ≤0.05 was considered as significant. Results: Four weeks endurance training, N.sativa extract and N.sativa extract with endurance trainings have significant effect on reduction of FBS, insulin resistance and HbA1c of diabetic rats (P- value≤0.05). Conclusion: Four weeks N.sativa extract and endurance training have hypoglycemic effects in diabetic rats but they have no interactional effects.