The Effect of 6 Weeks Resistance Training and High-Intensity Interval Training on Glut-4 Gene Expression of Diabetic Rats

Objective: GLUT4 glucose transporter content and glucose transport capacity are closely correlated in muscle. The purpose of current study was to evaluate the effect of 6 weeks of resistance training and HighIntensity Interval Training (HITT) on Glut4 gene expression in type 2 diabetes mellitus (T2DM) by high fat diet and STZ. Materials and Methods: This study was done on 32 male Wistar in Baqiyatallah University of Medical SciencesTehran. The study sample consisted of 32 male Wistar 10 week old weighting 220 ±20 gr which were divided into 4 obese groups. One diabetic group had to do resistance training and another group did HIIT. One more diabetic group and the healthy group did not do any activities. At the end, the amount of their left ventricular GLUT4 was measured. Independent ttest and one way ANOVA were used to examine the results. Results: The expression of Glut4 in the left ventricle of diabetic rats was 0.72 lower than that of the nondiabetic group, due to T2DM induction (Pvalue:0.029). There was a significant difference between the groups in expressing Glut4 in the left ventricle. The post hoc test confirmed a significant increase in the expression of Glut4 in the resistance and HIIT group compared to the control group (Pvalue:0.017 and Pvalue:0.05). Conclusion: However, there was no significant difference in expression of Glut4 between the two groups of resistance and HIIT. Our findings showed that T2DM patients with cardiovascular disease can improve their problem by performing physical activity.