Title of article :
Antibacterial Activity of Bis(Indolyl) Methane Derivatives against Staphylococcus Aureus
Author/Authors :
Bahe ، Anil Kumar Heterocyclic Synthesis and Electro Analytical Laboratory, Department of Chemistry - Dr. Harisingh Gour Central University , Das ، Ratnesh Heterocyclic Synthesis and Electro Analytical Laboratory, Department of Chemistry - Dr. Harisingh Gour Central University , Naikoo ، Gowhar Ahmad Department of Mathematics and Sciences - College of Arts and Applied Sciences - Dhofar University , Kosti ، Pankaj Heterocyclic Synthesis and Electro Analytical Laboratory, Department of Chemistry - Dr. Harisingh Gour Central University , Kashaw ، Sushil Department of Pharmaceutical Science - Dr. Hari Singh Gour University
Abstract :
In the present study, we successfully synthesized a series of indoles with a variety of aromatic aldehydes via one-pot route. The excellent results of the bis(indoly) methane (BIM) derivatives was obtained at the presence of 5.0 mol% p-toluene sulfonic acid in acetonitrile at room temperature using conventional process. All the as-synthesized compounds were bioactive. The synthesized BIM derivatives were evaluated for the antibacterial activity (in vitro) against the Staphylococcus aureus, and the results were compared with the standard Kanamycin. The results confirmed that, majority of the as-synthesized compounds revealed splendid antibacterial activity.
Keywords :
Antibacterial Activity , Bis(indolyl) methane derivatives , Catalyst , Kanamycin , Staphylococcus aureus (MTCC1144)
Journal title :
Advanced Journal of Chemistry-Section A: Theoretical, Engineering and Applied Chemistry
Journal title :
Advanced Journal of Chemistry-Section A: Theoretical, Engineering and Applied Chemistry
