Title of article :
Neurological Disorders due to Recurrent Hypoglycemia
Author/Authors :
Oudat, Mazen Neurologist and Internist at Royal Medical Services - King Hussein Hospital, Amman, Jordan , Al Domour, Aktham Neurologist and Internist at Royal Medical Services - King Hussein Hospital, Amman, Jordan , Al Shiab, Awni Fellow Neurology and Internist at Royal Medical Services - King Hussein Hospital, Amman, Jordan , Al Adamat, Mohamad Fellow Neurology and Internist at Royal Medical Services - King Hussein Hospital, Amman, Jordan , Al Etan, Shahir Fellow Neurology and Internist at Royal Medical Services - King Hussein Hospital , Al Dwarii, Abed Rahim Senior Specialist in Neurology and Internal Medicine at Royal Medical Services - King Hussein Hospital, Amman, Jordan
Abstract :
The most important material for the brain tissues is glucose .The brain utilizes around (25%) of the body's glucose, and it's metabolism thought to be primarily by astrocytes through non-insulin dependent (GLUT-1) transporter and insulin dependent (GLUT-4) transporter, but the brain contains very limited stores of glycogen, and therefore it can't regulate it's function for long time without glucose.
So neuronal damage can lead to multiple neurological manifestations as a result of hypoglycemia acutely; stroke like symptoms, movement disorders (tremor, ataxia, difficulty of walking), seizures, coma and death; chronically and repetitive leads to cognitive impairment. Which means clinical picture appears according to the area of neuronal damage.
Keywords :
cerebral peduncle , Basal ganglia , Hypoxia , neuronal DNA , ischemia , WM: White Matter , N-Methyl-D-Aspartate receptor , NMDA receptor
Journal title :
International Journal Of Medical Investigation
