Title of article :
Synthesis of novel polymers containing Schiff base as potential antimutagenic and antimicrobial agents
Author/Authors :
Nartop ، Dilek Department of Polymer Engineering - Faculty of Technology - Düzce University , Tokmak ، Erkan Department of Chemistry - Institute of Science - Nevşehir Hacı Bektaş Veli University , Özkan ، Elvan Hasanoğlu Department of Chemistry - Faculty of Science - Gazi University , Kızıl ، Hamit Emre Department of Medical Laboratory Techniques - Vocational School of Health Services - Bayburt University , Öğütcü ، Hatice Department of Field Crops - Faculty of Agriculture - Ahi Evran University , Ağar ، Güleray Department of Biology - Faculty of Science - Atatürk University , Allı ، Sema Department of Polymer Engineering - Faculty of Technology - Düzce University
Abstract :
In this research study, two novel polymers including Schiff base were prepared by condensation reaction of polystyrene-A-NH2 with 5-nitro-2-thiophenecarboxaldehyde/or 5-(2-nitrophenyl)-2-furancarboxaldehyde. The synthesized polymers were evaluated using the elemental analysis, infrared spectroscopy (IR), gel permeation chromatography (GPC), thermal gravimetric analysis (TG/DTA). In addition, the antimicrobial and antimutagenic study of the polymers were reported. The antibacterial and antifungal activity were investigated using the diffusion method against pathogenic bacterial strains. PA-TC and PA-FC polymers exhibited the highest antimicrobial activity against the S. typhi H. and P. vulgaris, respectively. PA-FC polymer revealed the highest antifungal activity against C. albicans. The antimutagenic effects were evaluated using the sister chromatid exchange (SCE) and micronucleus (MN) methods against the sodium azide (NaN3) in human lymphocyte cells. The results demonstrated that the PA-FC polymer have strong antimutagenic properties, especially in the concentration of 20 μg/mL.
Keywords :
Polymers containing Schiff base , Polystyrene , A , NH2 , Antimicrobial activity , Antimutagenic effect , Sodium azide
Journal title :
Journal of Medicinal and Chemical Sciences
Journal title :
Journal of Medicinal and Chemical Sciences
