Author/Authors :
Ghaemi ، Mir Reza Department of Pediatrics - School of Medicine - Urmia University of Medical Sciences , Hemmati ، Sara Research Center for Immunodeficiencies, Children’s Medical Center Hospital - Tehran University of Medical Sciences , Rezaei ، Arezou Research Center for Immunodeficiencies, Children’s Medical Center Hospital - Tehran University of Medical Sciences , Sadr ، Maryam Molecular Immunology Research Center - Tehran University of Medical Sciences , Mohebbi ، Bahareh Research Center for Immunodeficiencies, Children’s Medical Center Hospital - Tehran University of Medical Sciences, Tehran , Ghaffaripour ، Hosseinali Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis And Lung Diseases (NRITLD) - Shahid Beheshti University of Medical Sciences , Rezaei ، Nima Department of Immunology - Research Center for Immunodeficiencies, Children’s Medical Center Hospita, School of Medicine - Tehran University of Medical Sciences , Mahdaviani ، Seyed Alireza Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis And Lung Diseases (NRITLD) - Shahid Beheshti University of Medical Sciences
Abstract :
There is strong evidence on the interaction of several genetic variations and environmental conditions in the etiology of asthma. Association of a disintegrin and metalloproteinase 33 (ADAM33) with asthma risk is not clear and shows diversity between nations and ethnicities. Several single nucleotide polymorphisms (SNP) of the ADAM33 gene are introduced and studied according to the disease onset and characteristics. The aim of our study is to determine the association of ADAM33 rs2280091 polymorphism and pediatric asthma in the Iranian population. A total of 63 asthma patients (aged 6-18) and 86 healthy controls were enrolled in our study. Asthma type, classification, and severity were defined. SNPs of the ADAM33 gene at rs2280091 (T1) were analyzed. Pulmonary function tests, total blood eosinophil count, and IgE count were also assessed. T1 genotype and allele frequencies were not associated with asthma risk in Iranian pediatric asthma. Atopic asthma subgroup and patients with normal eosinophil count showed association with ADAM33 rs2280091. Moreover, asthma patients with AG genotype showed lower pulmonary functions.
Keywords :
Asthma , ADAM33 , rs2280091 , Polymorphisms
