Adiponectin/TNF-α Ratio Following a Selected Aerobic Training in Sedentary Adult Obese Men

Background: Based on clinical studies, low adiponectin and high tumor necrosis factor alpha (TNF-α) are associated with obesity and related diseases such as type 2 diabetes and insulin resistance. Objectives: In this study, we aimed to investigate the effect of an aerobic training program on adiponectin, TNF-α, and adiponectin/TNF-α ratio in adult obese men. Patients and Methods: For this purpose, 24 sedentary adult obese men matched for age (38 ± 3.23 years) and body mass index (31.94 ± 3.26 kg/m2 ) were selected and divided into exercise (aerobic training) and control groups. Exercise subjects participated in an aerobic exercise training intervention for 12 weeks (3 times/week) and the control group did not participate in aerobic intervention. Anthropometric and biochemical data including fasting serum adiponectin, TNF-α, and adiponectin/TNF-α ratio were measured before and after aerobic training for each participant in each group. Data were analyzed by both independent and paired sample t test. Results: Compared to pre-training, fasting serum adiponectin decreased significantly (P = .019), but serum TNF-α was not changed by aerobic training (P = .057). A significant increase was observed in adiponectin/TNF-α ratio in exercise subjects after aerobic training (P = .008). Conclusions: Based on these data, we conclude that aerobic training intervention is associated with improved inflammatory profile in obese subjects.