Author/Authors :
Moradi, Ali Mohammad Department of Surgery - Trauma Research Center - Shiraz University of Medical Sciences, Shiraz , Aj, Omid Department of Surgery - Trauma Research Center - Shiraz University of Medical Sciences, Shiraz , Paydar, Shahram Department of Surgery - Trauma Research Center - Shiraz University of Medical Sciences, Shiraz , Ketabchi, Farzaneh Department of Physiology - School of Medicine - Shiraz University of Medical Sciences, Shiraz , Sheid Moosavi, Mostafa Department of Physiology - School of Medicine - Shiraz University of Medical Sciences, Shiraz , Bolandparvaz, Shahram Department of Surgery - Trauma Research Center - Shiraz University of Medical Sciences, Shiraz , Abassi, Hamid Reza Department of Surgery - Trauma Research Center - Shiraz University of Medical Sciences, Shiraz , Tamadon, Aryan Dokht Stem Cell and Transgenic Technology Research Center - Shiraz University of Medical Sciences, Shiraz , Mehrabani, Davood Stem Cell and Transgenic Technology Research Center - Shiraz University of Medical Sciences, Shiraz
Abstract :
Introduction: The effect of severe soft tissue injury on the severity of hemorrhagic shock is still unknown. Therefore, the present study was aimed to determine hemodynamic and metabolic changes in traumatic/hemorrhagic shock in an animal model. Methods: Forty male rats were randomly divided into 4 equal groups including sham, hemorrhagic shock, soft tissue injury, and hemorrhagic shock + soft tissue injury groups. The changes in blood pressure, central venous pressure (CVP) level, acidity (pH), and base excess were dynamically monitored and comparedsented. Results: Mean arterial blood pressure decreased significantly in hemorrhagic shock (df: 12; F=10.9; p<0.001) and severe soft tissue injury + hemorrhagic shock (df: 12; F=11.7; p<0.001) groups 15 minutes and 5 minutes after injury, respectively. A similar trend was observed in CVP in severe soft tissue injury + hemorrhagic shock group (df: 12; F=8.9; p<0.001). After 40 minutes, pH was significantly lower in hemorrhagic shock (df: 12; F=6.8; p=0.009) and severe soft tissue injury + hemorrhagic shock (df: 12; F=7.9; p=0.003) groups. Base excess changes during follow ups have a similar trend. (df: 12; F=11.3; p<0.001). Conclusion: The results of this study have shown that the effect of hemorrhage on the decrease of mean arterial blood pressure, CVP, pH, and base excess is the same in the presence or absence of soft tissue injury.
Keywords :
Shock , hemorrhagic , soft tissue injuries , hemodynamics
