Author/Authors :
Ghasemvand, Fariba Enzyme Technology Lab - Genetics & Metabolism Research Group -Pasteur Institute of Iran, Tehran, Iran , Biazar, Esmaeil Department of Biomaterials Engineering - Islamic Azad University,Tonekabon Branch , Iran , Tavakolifard, Sara Department of Chemistry - Islamic Azad UniversityScience and Research Branch, Yazd, Iran , Khaledian, Mohammad Department of Biomaterials Engineering - Islamic Azad University,Tonekabon Branch , Iran , Rahmanzadeh, Saeid Enzyme Technology Lab - Genetics & Metabolism Research Group -Pasteur Institute of Iran, Tehran, Iran , Momenzadeh, Daruosh Brain and Spinal Injury Research Center - Tehran University of Medical Sciences, Iran , Afroosheh, Roshanak Department of Biomaterials Engineering - Islamic Azad University,Tonekabon Branch , Iran , Zarkalami, Faezeh Department of Biomaterials Engineering - Islamic Azad University,Tonekabon Branch , Iran , Shabannezhad, Marjan Department of Biomaterials Engineering - Islamic Azad University,Tonekabon Branch , Iran , Hesami Tackallou, Saeed Department of Biology - Islamic Azad University Garmsar Branch, Iran , Massoudi, Nilofar Department of Anesthesiology - Faculty of Medicine - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Heidari Keshel, Saeed Proteomics Research center - Shahid Beheshti University of medical sciences, Tehran, Iran
Abstract :
Aim: The aim of this study was to design multi-walled carbon nanotubes (MWCNTs) loaded with paclitaxel (PTX) anti-cancer
drug and investigate its anti-cancerous efficacy of human gastric cancer.
Background: Carbon nanotubes (CNTs) represent a novel nano-materials applied in various fields such as drug delivery
due to their unique chemical properties and high drug loading.
Patients and methods: In this study, multi-walled carbon nanotubes (MWCNTs) pre-functionalized covalently with a
paclitaxel (PTX) as an anti-cancer drug and evaluated by different analyses including, scanning electron microscope
(SEM), particle size analyzer and cellular analyses.
Results: A well conjugated of anti-cancer drug on the carbon nanotube surfaces was shown. This study demonstrates that the
MWCN-PTX complex is a potentially useful system for delivery of anti-cancer drugs. The flow cytometry, CFU and MTT
assay results have disclosed that MWCNT/PTXs might promote apoptosis in MKN-45 gastric adenocarcinoma cell line.
Conclusion: According to results, our simple method can be designed a candidate material for chemotherapy. It has presented
a few bio-related applications including, their successful use as a nano-carriers for drug transport.
Keywords :
Multi-walled carbon nanotubes , Paclitaxel , Structural investigations , Gastric cancer , MKN-45 cell line
