Author/Authors :
Wojciechowski, Valery V Department of Hospital Therapy and Pharmacology - Amur State Medical Academy - 675000 Blagoveshchensk, Russia , Calina, Daniela Department of Clinical Pharmacy - University of Medicine and Pharmacy of Craiova - Petru Rares - 200349 Craiova, Romania , Tsarouhas, Konstantinos Cardiological Department - University Hospital of Larissa - Larissa, Greece , Pivnik, Alexander V. Department of Hematology-Oncology and Secondary Immunodeficient Diseases - D.D. Pletnev Moscow Clinical Research and Practical Centre of Health Department - 111123 Moscow, Russia , Sergievich, Alexander A. School of Arts - Culture and Sports - Far Eastern Federal University - 690022 Vladivostok, Russia , Kodintsev, Vladimir V. School of Biomedicine - Far Eastern Federal University - 690022 Vladivostok, Russia. , Filatova, Ekaterina A Department of Hematology - Amur Regional Clinical Hospital - 675000 Blagoveshchensk, Russia , Ozcagli, Eren Department of Pharmaceutical Toxicology - Faculty of Pharmacy - Istanbul University - Beyazit - Istanbul 34116, Turkey , Docea, Anca Oana Department of Toxicology - University of Medicine and Pharmacy of Craiova - Petru Rares - 200349 Craiova - Romania , Letitia Arsene, Andreea Department of Pharmaceutical Microbiology - Faculty of Pharmacy - “Carol Davila” University of Medicine and Pharmacy - 6 - TraianVuia Street - sector 2 - 020956 Bucharest, Romania , Gofita, Eliza Department of Toxicology - University of Medicine and Pharmacy of Craiova - Petru Rares - 200349 Craiova - Romania , Tsitsimpikou, Christina Department of Hazardous Substances - General Chemical State Laboratory of Greece - Mixtures & Articles - 16 An. Tsocha Str - Athens 115121, Greece , Tsatsakis, Aristidis M SEC Nanotechnology - Far Eastern Federal University - 690022 Vladivostok - Russia - Forensic Sciences and Toxicology Department - Medical School - University of Crete - P.O. Box 139371003 Heraklion - Crete - Greece - Scientific Educational Center of Nanotechnology - Federal Scientific Center of Hygiene - Far Eastern Federal University - F.F. Erisman - Moscow 690950 - Russian Federation , Golokhvast, Kirill S Department of Hospital Therapy and Pharmacology - Amur State Medical Academy - 675000 Blagoveshchensk, Russia - Department of Clinical Pharmacy - University of Medicine and Pharmacy of Craiova - Petru Rares - 200349 Craiova, Romania
Abstract :
Physicians often come across with cases of vitamin K antagonists–dependent coagulopathy for reasons such as accidental use of the vitamin K antagonists (VKA), excessive administration of prescribed anticoagulants of indirect
action or not reported administration of vitamin K antagonists due to memory impairment and/or other mental
disorders, even deliberate use thereof (attempt to murder or suicide). Rodenticide-poisoning (coumarins, warfarins)
via food or occupational accidents are difficult to diagnose. This article discusses different types of acquired vitamin
K-dependent coagulopathy. Differential diagnosis is primarily based on patient statements before additional causes
of vitamin K deficiency are explored. Even when pathological vitamin K deficiency is not determined, appropriate
and urgent medical treatment is necessary: administration of fresh frozen plasma or concentrated factors of the
prothrombin complex, administration of vitamin K remedies along with symptomatic therapy. With early diagnosis and prescription of appropriate therapy, prognosis is favorable.
