Author/Authors :
Ruiz-Lozano Pilar Stanford Cardiovascular Institute - Stanford - CA 94305, USA , Mahmoudi Morteza Stanford Cardiovascular Institute - Stanford - CA 94305, USA , Yang Phillip C. Stanford Cardiovascular Institute - Stanford - CA 94305, USA , Bernstein Daniel Stanford Cardiovascular Institute - Stanford - CA 94305, USA , Serpooshan Vahid Stanford Cardiovascular Institute - Stanford - CA 94305, USA , Zhao Mingming Department of Pediatrics - Stanford University - 300 Pasteur Dr. Stanford - CA 94305, USA , Matsuura Yuka Division of Cardiovascular Medicine - Stanford University - 300 Pasteur Dr. Stanford - CA 94305, USA , Laurent Sophie Department of General - Organic - and Biomedical Chemistry - NMR and Molecular Imaging Laboratory - University of Mons - Avenue Maistriau - 19 - B-7000 Mons, Belgium
Abstract :
Tissue engineering utilizes porous scaffolds
as template to guide the new tissue growth.
Clinical application of scaffolding biomaterials
is hindered by implant-associated infection
and impaired in vivo visibility of construct in
biomedical imaging modalities. We recently
demonstrated the use of a bioengineered type I
collagen patch to repair damaged myocardium.
By incorporating superparamagnetic iron
oxide nanoparticles into this patch, here, we
developed an MRI-visible scaffold. Moreover, the embedded nanoparticles impeded the growth
of Salmonella bacteria in the patch. Conferring anti-infection and MRI-visible activities to the
engineered scaffolds can improve their clinical outcomes and reduce the morbidity/mortality of
biomaterial-based regenerative therapies.
Keywords :
Antibacterial properties , Collagen scaffold , Magnetic resonance imaging , SPION , Superparamagnetic iron oxide nanoparticles , Tissue engineering
