Author/Authors :
Azarpira, Negar Transplant Research Center - Shiraz University of Medical Science, Iran , Safaie, Akbar Pathology Department - Shiraz University of Medical Science, Iran , Monabati, Ahmad Pathology Department - Shiraz University of Medical Science, Iran , Hosseinzadeh, Masudd Pathology Department - Shiraz University of Medical Science, Iran , Noori, Sadat Pathology Department - Shiraz University of Medical Science, Iran , Moini, Maryam Gastroenterology Research Center - Department of Internal Medicine - Shiraz University of Medical Science, Iran , Rahimi, Alireza Gastroenterology Research Center - Department of Internal Medicine - Shiraz University of Medical Science, Iran , Heidari, Tahereh Transplant Research Center - Shiraz University of Medical Science, Iran , Rahsaz, Marjan Transplant Research Center - Shiraz University of Medical Science, Iran
Abstract :
Anaplastic large cell lymphoma (ALCL) is a distinct pathologic entity with characteristic morphologic, im¬munophenotypic and cytogenetic
features. Obstructive symptoms are rare presentation of ALCL. We report a 16-year-old boy who initially presented with dysphagia. Upper
gastrointestinal endoscopy revealed severe stenosis with an infiltrative process starting from 24 cm of incisors in lower esophagus Esophageal
mucosal biopsy demonstrated lymphomatous involvement that ancillary tests confirmed the diagnosis of ALCL, ALK (kinase-positive), and
PAX5 positive. The patient responded to CHOP-based chemotherapy. This case illustrated an unusual presentation of primary Non Hodgkin
lymphoma of esophagus.
Keywords :
PAX5 , Anaplastic large cell lymphoma , Esophagus , stricture
